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International Journal of Zoology and Applied Biosciences Research Article

Scientific evaluation of siddha herbal decoction Manjal Noi Kudineer: Insights into its antipyretic and anti-inflammatory mechanisms

Senthil Kumar P, Elansekaran S and Bharath Kumar G

Year : 2025 | Volume: 10 | Issue: 6 | Pages: 300-305

doi: https://doi.org/10.55126/ijzab.2025.v10.i06.035

Received on: 22/09/2025

Revised on: 27/10/2025

Accepted on: 16/11/2025

Published on: 01/12/2025

  • Senthil Kumar P, Elansekaran S and Bharath Kumar G ( 2025).

    Scientific evaluation of siddha herbal decoction Manjal Noi Kudineer: Insights into its antipyretic and anti-inflammatory mechanisms

    . International Journal of Zoology and Applied Biosciences, 10( 6), 300-305.

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Abstract

Manjal noi kudineer (MNK) is a classical Siddha formulation documented in the Siddha Pharmacopoeia of India, traditionally employed for its detoxifying, anti-inflammatory, and antipyretic properties. Despite its long-standing use, systematic pharmacological validation is limited. This study aimed to evaluate the antipyretic and anti-inflammatory potential of MNK in experimental animal models. Female Wistar rats were used to assess antipyretic activity via Brewer’s yeast-induced pyrexia, while carrageenan-induced paw edema in Wistar rats was employed for anti-inflammatory evaluation. MNK was administered orally at doses of 50, 250, and 500 mg/kg. Rectal temperature and paw edema were recorded at specified intervals and compared with negative (vehicle) and positive (paracetamol/diclofenac) controls. MNK at 500 mg/kg significantly reduced pyrexia, comparable to paracetamol. Similarly, MNK dose-dependently inhibited paw edema, with the highest dose approaching the efficacy of diclofenac. MNK exhibits significant antipyretic and anti-inflammatory effects in vivo, supporting its traditional therapeutic use and providing a foundation for further pharmacological studies.

Keywords

Manjal Noi Kudineer, Siddha medicine, Antipyretic activity, Anti-inflammatory activity.

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    © The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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