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International Journal of Zoology and Applied Biosciences Research Article
Protective effect of Rhinacanthus nasutus on brain oxidative stress and lipid peroxidation in streptozotocin induced diabetic male albino rat
Ganesh Konda, K. Vanaja, Anand konkala, P. Sashikiran, R. Chandra Mouli, T Dinaker Chinna
Year : 2026 | Volume: 11 | Issue: 1 | Pages: 318-325
Received on: 27/11/2025
Revised on: 25/12/2025
Accepted on: 22/01/2026
Published on: 31/01/2026
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Ganesh Konda, K. Vanaja, Anand konkala, P. Sashikiran, R. Chandra Mouli, T Dinaker Chinna ( 2026).
Protective effect of Rhinacanthus nasutus on brain oxidative stress and lipid peroxidation in streptozotocin induced diabetic male albino rat
. International Journal of Zoology and Applied Biosciences, 11( 1), 318-325.
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Abstract
This research was to examine the protective effects of Rhinacanthus nasutus in streptozotocin (STZ)-induced diabetic rats through oral supplementation of 200 mg/kg body weight. Diabetes was induced in adult male albino rats weighing 200 g by intraperitoneal administration of STZ (40 mg/kg body weight). Glibenclamide (50 mg/kg body weight) was used as the standard drug. The diabetic rats exhibited higher levels of blood glucose and MDA content in their brain homogenates, along with decreased body weight, Superoxide dismutase, catalase, glutathione peroxidase activities, and glutathione levels in brain tissue. However, diabetic rats treated with oral supplements of Rhinacanthus nasutus extracts and glibenclamide showed reduced blood glucose levels and MDA, as well as increased Superoxide dismutase and catalase activities, GSH levels in the brain, and higher body weight. These results suggest that Rhinacanthus nasutus extract therapy has a protective effect against the progression of diabetes by reducing oxidative stress in the brain.
Keywords
Diabetes, Rhinacanthus nasutus, Oxidative Stress markers, Brain tissue.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
