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International Journal of Zoology and Applied Biosciences Research Article
Prospective evaluation of drug-therapy problems and adverse drug reactions in colorectal cancer patients
Vinod Kumar Mugada and Vidyadhara Suryadevara
Year : 2025 | Pages: 389-397
Received on: 11/09/2025
Revised on: 22/10/2025
Accepted on: 15/11/2025
Published on: 30/11/2025
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Vinod Kumar Mugada and Vidyadhara Suryadevara( 2025).
Prospective evaluation of drug-therapy problems and adverse drug reactions in colorectal cancer patients
. International Journal of Zoology and Applied Biosciences, 10( 6), 389-397.
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Abstract
Drug therapy problems (DTPs) are common in oncology and can compromise treatment outcomes, particularly in colorectal cancer (CRC), where complex regimens are used. This prospective observational study evaluated the prevalence, causes, and predictors of DTPs in CRC patients receiving systemic anticancer therapy. A total of 200 patients were enrolled and followed during the first two treatment cycles. Over half of the cohort experienced at least one DTP, with dose selection, drug selection, and patient-related issues being the most frequent causes. Oral anticancer agents were used in nearly half of the cohort, and their use was independently associated with increased DTP risk. The most commonly implicated drugs in adverse drug reactions (ADRs) were 5-fluorouracil and oxaliplatin, with stomatitis and neuropathy being prominent toxicities. Approximately one-third of ADRs were classified as serious, with most deemed probable in causality assessments. Predictors of DTPs included poor performance status, polypharmacy, comorbidities, and use of oral therapies. While guideline adherence was high for antiemetics and G-CSF support, venous thromboembolism prophylaxis remained underutilized. This study provides a comprehensive overview of early DTPs in CRC, identifies vulnerable subgroups, and highlights the need for improved medication safety practices, especially in oral chemotherapy management and supportive care optimization.
Keywords
Drug therapy problems, Colorectal cancer, Adverse drug reactions, Oral chemotherapy.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
