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International Journal of Zoology and Applied Biosciences Research Article
Preparation and characterization of mouth dissolving tablets of indomethacin using banana peel powder as a natural super disintegrant
Srilekhya Ketha, Preethi Pudi and Srinivasarao Y
Year : 2025 | Pages: 715-721
Received on: 10/10/2025
Revised on: 27/10/2025
Accepted on: 26/11/2025
Published on: 01/12/2025
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Srilekhya Ketha, Preethi Pudi and Srinivasarao Y( 2025).
Preparation and characterization of mouth dissolving tablets of indomethacin using banana peel powder as a natural super disintegrant
. International Journal of Zoology and Applied Biosciences, 10( 6), 715-721.
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Abstract
Mouth dissolving tablets are meant for administration to the patients who cannot swallow, such as elderly, stroke victims, bedridden patients, patients affected by renal failure, and the patients who refuse to swallow, such as pediatric, geriatric, and psychiatric patients. The aim of the study is to formulate mouth dissolving tablet of Indomethacin for the pain management of Rheumatoid Arthritis and to improve the efficacy and patient compliance. In the present work, fast dissolving tablets of Indomethacin were prepared by direct compression method using Banana peel powder as natural super disintegrant with a view to enhance patient compliance and to avoid hepatic first pass metabolism and to improve its bioavailability. The prepared formulations of tablets were evaluated for hardness,thickness, friability, drug content uniformity, wetting time, disintegration and in-vitro dissoution studies.Thus the study leads that Musa paradisicum (Banana peel powder)releases high amount of drug content which is used as natural super disintegrant.
Keywords
Indomethacin, Mouth dissolving tablets, Banana peel powder, Natural super disintegrant.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
