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International Journal of Zoology and Applied Biosciences Research Article
Neuroprotective potential of Dictyota bartayresiana crude extracts: An in vitro study using neuroblastoma cell lines (SH-SY5Y cell line)
Vijayaprabhaa U, Aravindhan R , Magesh KT, Sathya Kumar M, Sivachandran A , Swaathi R
Year : 2026 | Volume: 11 | Issue: 1 | Pages: 61-67
Received on: 22/10/2025
Revised on: 27/11/2025
Accepted on: 21/12/2025
Published on: 01/01/2026
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Vijayaprabhaa U, Aravindhan R , Magesh KT, Sathya Kumar M, Sivachandran A , Swaathi R( 2026).
Neuroprotective potential of Dictyota bartayresiana crude extracts: An in vitro study using neuroblastoma cell lines (SH-SY5Y cell line)
. International Journal of Zoology and Applied Biosciences, 11( 1), 61-67.
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Abstract
Neurodegenerative diseases, characterized by progressive neuronal deterioration, pose a significant and growing global health challenge due to their increasing prevalence with an aging population and limitations of current symptomatic treatments. This study addresses the urgent need for novel therapeutic interventions by investigating the neuroprotective potential of crude extracts from the marine alga Dictyota bartayresiana. Using an in vitro model with SH-SY5Y neuroblastoma cells, the study employed MTT assays to evaluate both the extract's cytotoxicity and its capacity to alleviate hydrogen peroxide (H?O?)-induced oxidative stress. Key findings reveal that the Dictyota bartayresiana extract exhibits a concentration-dependent, biphasic effect. An intrinsic cytotoxic concentration (IC??) of 63.53 µg/mL was determined. Importantly, the extract demonstrated significant neuroprotection against H?O?-induced oxidative stress within an optimal range of 25–50 µg/mL. However, protective effects waned at both lower and higher concentrations, highlighting a complex dose-response. These results underscore that Dictyota bartayresiana contains compounds with both neuroprotective and potentially cytotoxic properties, necessitating precise dose optimization for therapeutic application. The study highlights the promise of marine natural products as sources for new neuroprotective agents and emphasizes the need for further research to identify specific bioactive compounds and elucidate the molecular mechanisms underlying this intricate dose-dependent efficacy.
Keywords
Dictyota bartayresiana, Neuroprotection, Oxidative stress, SH-SY5Y cells, Biphasic dose-response, Neurodegenerative diseases.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
