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International Journal of Zoology and Applied Biosciences Research Article
Neuroprotective effects of herbal medicines
Mohini Rangala, Kada Lakshmi Monica, Modalavalasa Anusha, Ashish Gardi, Gundapuneni Srinidhi and Boddu Yamini devi
Year : 2025 | Pages: 383-388
Received on: 10/09/2025
Revised on: 22/10/2025
Accepted on: 01/11/2025
Published on: 30/11/2025
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Mohini Rangala, Kada Lakshmi Monica, Modalavalasa Anusha, Ashish Gardi, Gundapuneni Srinidhi and Boddu Yamini devi( 2025).
Neuroprotective effects of herbal medicines
. International Journal of Zoology and Applied Biosciences, 10( 6), 383-388.
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Abstract
The brain, as the central regulator of all bodily systems, requires robust protection against aging and neurodegenerative diseases. This review explores the neuroprotective potential of traditional medicinal herbs, particularly those from the Indonesian Cabe Puyang Manuscript. Among 31 herbs identified, 12 including Zingiber officinale, Centella asiatica, and Moringa oleifera—demonstrated strong central nervous system activity due to their antioxidant and anti-inflammatory properties. Neurodegenerative conditions such as Alzheimer’s, Parkinson’s, and dementia are characterized by progressive neuronal loss and the accumulation of misfolded proteins like amyloid-β and α-synuclein. Herbal bioactive compounds offer promising neuroprotection by reducing oxidative stress, inhibiting pathogenic enzymes, and promoting neuronal growth. Additionally, herbal medicines show therapeutic potential in managing autoimmune disorders like multiple sclerosis and in mitigating damage from ischemic stroke through multi-targeted mechanisms, including modulation of mitophagy. Gut microbiota dysbiosis, a newly recognized factor in Alzheimer’s disease, may also be regulated through herbal interventions. Phytochemicals such as flavonoids, alkaloids, phenylpropanoids, and isoprenoids found in traditional and Ayurvedic herbs contribute to cognitive health by countering oxidative damage and inflammation. Collectively, these findings highlight the therapeutic potential of natural products and traditional herbs in preventing and managing neurodegenerative diseases, warranting further research and drug development efforts.
Keywords
Neuroprotection, Herbal medicine, Neurodegenerative diseases, Phytochemicals; Oxidativestress.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
