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International Journal of Zoology and Applied Biosciences Research Article
Molecular recognition assisted targeting and controlled drug release mechanisms
Maniraj K, Saalini Vellivel, Swathi T, Senthilkumar GP and Sujitha K
Year : 2025 | Pages: 415-418
Received on: 25/09/2025
Revised on: 18/10/2025
Accepted on: 25/11/2025
Published on: 01/12/2025
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Maniraj K, Saalini Vellivel, Swathi T, Senthilkumar GP and Sujitha K ( 2025).
Molecular recognition assisted targeting and controlled drug release mechanisms
. International Journal of Zoology and Applied Biosciences, 10( 6), 415-418.
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Abstract
Molecular recognition plays a central role in the design of targeted and controlled drug delivery systems, enabling selective therapeutic action and minimizing off-target effects. This study investigates ligand–receptor interactions, supramolecular assembly, and stimuli-responsive release mechanisms using computational modeling and theoretical evaluation. A simulated nanoparticle platform incorporating functionalized ligands was analyzed for binding affinity, targeting efficiency, and release kinetics. Molecular docking and binding free-energy calculations demonstrated high-affinity interactions between functionalized nanocarriers and targeted receptors, supporting receptor-mediated internalization. Kinetic modeling revealed that recognition-driven interactions significantly enhanced sustained and controlled drug release profiles compared to passive diffusion-based systems. The study highlights the crucial role of molecular recognition parameters such as ligand geometry, receptor density, and binding thermodynamics—in improving precision drug delivery. These findings provide a conceptual framework for designing next-generation smart drug delivery systems and offer guidance for future experimental and translational studies.
Keywords
Molecular recognition, Drug delivery, Controlled release, Ligand– receptor interaction, Nanocarriers.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
