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International Journal of Zoology and Applied Biosciences Research Article

Median lethal dose (LD50) estimation of cypermethrin and profenofos in swiss albino mice (Mus musculus)

Md Sarfaraz Nawaz, Asif Iqbal and Md Equbal Ahmad

Year : 2024 | Volume: 9 | Issue: 3 | Pages: 6-10

doi: https://doi.org/10.55126/ijzab.2024.v09.i03.002

Received on: 17/02/2024

Revised on: 21/02/2024

Accepted on: 21/04/2024

Published on: 01/05/2024

  • Md Sarfaraz Nawaz, Asif Iqbal and Md Equbal Ahmad( 2024).

    Median lethal dose (LD50) estimation of cypermethrin and profenofos in swiss albino mice (Mus musculus)

    . International Journal of Zoology and Applied Biosciences, 9( 3), 6-10.

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Abstract

Present study was undertaken to determine the Oral median lethal dose (LD50) of Cypermethrin, a pyrethroid and Profenofos, an organophosphate pesticide in male and female Swiss albino mice. The selected doses of Cypermethrin based on the pilot study were 200, 225, 250, 275 and 300 mg/kg B.W. for male and 350, 375, 400, 425 and 450 mg/kg B.W for female animals. Corresponding doses of Profenofos based on the pilot study was found to be 10, 15, 20, 25 and 30 mg/kg B.W for male and 20, 25, 30, 35 and 40 mg/kg B.W for female. Pesticide was dissolved in corn oil and administered orally to different groups of male and female mice, consisting of 10 animals in each group. Possible death of animals was monitored up to 96 h to calculate the median lethal dose (LD50) of CYP. The results obtained in this study suggest that oral LD50 of the CYP and PFF dissolved in corn oil was found to be (249.06 ± 30.75, 406.38 ± 64.28) and (24.26 ±6.43, 39.67 ±6.2) mg/kg B.W. respectively in male and female Swiss albino mice.

Keywords

Oral LD 50, Cypermethrin, Profenofos, Probit analysis.

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    © The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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