Archives
International Journal of Zoology and Applied Biosciences Research Article
In vivo assessment of wound closure and biocompatibility of nanochitosan-polyvinyl alcohol-glycerol films in experimental animal model
Rosemol Jacob M, Amruth P, Akshay P, Stephy Rose K.V, Anandan R, Suseela Mathew
Year : 2023 | Volume: 8 | Issue: 6 | Pages: 77-83
Received on: 05/11/2023
Revised on: 19/11/2023
Accepted on: 13/12/2023
Published on: 31/12/2023
-
Rosemol Jacob M, Amruth P, Akshay P, Stephy Rose K.V, Anandan R, Suseela Mathew ( 2023).
In vivo assessment of wound closure and biocompatibility of nanochitosan-polyvinyl alcohol-glycerol films in experimental animal model
. International Journal of Zoology and Applied Biosciences, 8( 6), 77-83.
-
click to view the cite format
Abstract
The need for innovative wound dressings has arisen due to injuries from second intention healing and their management is associated with high costs. Modern dressings not only protect wounds but also promote proliferation of cells and tissue regeneration. Patient compliance is crucial, ensuring that the dressing removal does not harm the newly regenerated tissue. In this study, nano-chitosan polyvinyl alcohol- glycerol (NCH-PVA-GLY) transparent wound dressing was developed that expedites tissue repair and can be removed through an external stimulus without disrupting the regenerated tissue. This dressing efficiently absorbs excess wound exudate while maintaining proper hydration. Evaluation in male Wistar rats with wounds revealed that the dressing, when applied for 16 days, resulted in minimal inflammation and denser connective tissue compared to wounds devoid of dressings. The dressing exhibited enhanced re-epithelization and angiogenesis, facilitating effective wound closure. The exposure of the resultant dressing, to the incised wound facilitated complete wound closure in 16 days, suggesting the effectiveness of the dressings to cure superficial wound.
Keywords
Nanochitosan, Polyvinyl alcohol, Glycerol, Dressing films, Wound healing.
-
Full Article PDF (
44)
- View HTML Article
Copy Rights
© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
