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International Journal of Zoology and Applied Biosciences Review Article
Genetic and molecular landscape of pediatric leukemia: from pathogenesis to precision therapeutics
Purna Nagasree K, Sai Jaya Varshini Thalachandra, Santhi Priya Tirlangi, Dhanunjay Kumar Sureddi, Sneharika Tothadi, Hari Krishna Sivvala, Jahnavi Sirisetti
Year : 2025 | Pages: 680-686
Received on: 17/10/2025
Revised on: 27/10/2025
Accepted on: 22/11/2025
Published on: 01/12/2025
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Purna Nagasree K, Sai Jaya Varshini Thalachandra, Santhi Priya Tirlangi, Dhanunjay Kumar Sureddi, Sneharika Tothadi, Hari Krishna Sivvala, Jahnavi Sirisetti( 2025).
Genetic and molecular landscape of pediatric leukemia: from pathogenesis to precision therapeutics
. International Journal of Zoology and Applied Biosciences, 10( 6), 680-686.
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Abstract
Pediatric leukemia represents the most common malignancy in children, accounting for nearly one-third of all pediatric cancers. Despite remarkable improvements in survival outcomes, it remains a leading cause of cancer-related mortality among children worldwide. Advances in molecular diagnostics, next-generation sequencing, and computational biology have unveiled complex genetic and epigenetic networks driving leukemogenesis. Key oncogenic mutations such as ETV6-RUNX1, FLT3, KMT2A (MLL), TP53, WT1, and NOTCH1 disrupt normal hematopoietic regulation, differentiation, and apoptosis. These discoveries have propelled the development of precision therapeutics, including kinase inhibitors, monoclonal antibodies, and immunotherapy. This review consolidates current evidence on the epidemiology, molecular etiology, pathophysiology, and therapeutic innovations in pediatric leukemia, highlighting the translational relevance of genetic alterations and their potential for targeted interventions.
Keywords
Pediatric leukemia, Genetic mutations, Molecular pathogenesis, Targeted therapy.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
