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International Journal of Zoology and Applied Biosciences Research Article
Gene identification and molecular insights into the genetic basis of type II diabetes
Pradeepa Alagupandi, Anto Suganya. R, Devasena B, Tehseen Javed and Jenifer E
Year : 2025 | Pages: 522-526
Received on: 26/09/2025
Revised on: 22/10/2025
Accepted on: 24/11/2025
Published on: 01/12/2025
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Pradeepa Alagupandi, Anto Suganya. R, Devasena B, Tehseen Javed and Jenifer E( 2025).
Gene identification and molecular insights into the genetic basis of type II diabetes
. International Journal of Zoology and Applied Biosciences, 10( 6), 522-526.
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Abstract
Type II diabetes mellitus (T2DM) is a complex metabolic disorder influenced by both genetic and environmental factors. Despite extensive research, the identification of key regulatory genes and their molecular mechanisms remain a major challenge. This study investigates the genetic determinants of T2DM using integrated bioinformatics, gene expression profiling, and molecular pathway analysis. Candidate genes were identified from high-throughput datasets, followed by functional annotation and molecular docking of their protein targets with antidiabetic phytochemicals. Key genes including TCF7L2, PPARG, KCNJ11, SLC30A8, IRS1, and FTO showed significant dysregulation and strong associations with insulin secretion, ?-cell function, glucose homeostasis, and metabolic signaling. Pathway analysis confirmed their involvement in PI3K-AKT, AMPK, Wnt, and mTOR signaling pathways. Structural modelling and docking highlighted TCF7L2 and PPARG as the most promising therapeutic targets. This integrative study provides new molecular insights into T2DM pathogenesis and identifies gene-level targets for future drug development.
Keywords
Type II diabetes, Gene identification, Molecular analysis, TCF7L2, PPARG.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
