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International Journal of Zoology and Applied Biosciences Review Article

Exploring the anticancer potential of medicinal plants against hepatic cancer: A systematic review

Kumaresan Anbu, Vijai Krishna V, Anitha W, Vickneswari M and Sujitha K

Year : 2025 | Pages: 81-84

doi: https://doi.org/10.55126/ijzab.2025.v10.i06.SP019

Received on: 15/09/2025

Revised on: 17/10/2025

Accepted on: 24/10/2025

Published on: 12/11/2025

  • Kumaresan Anbu, Vijai Krishna V, Anitha W, Vickneswari M and Sujitha K ( 2025).

    Exploring the anticancer potential of medicinal plants against hepatic cancer: A systematic review

    . International Journal of Zoology and Applied Biosciences, 10( 6), 81-84.

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Abstract

Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related mortality worldwide, with limited therapeutic options and frequent adverse effects associated with conventional treatments. Medicinal plants have emerged as a promising source of bioactive compounds with potential anticancer properties. This systematic review aims to consolidate current evidence on the efficacy of medicinal plants against liver cancer cells, highlighting their mechanisms of action, bioactive constituents, and therapeutic potential. Relevant studies published between 2000 and 2025 were retrieved from databases including Scopus, PubMed, Web of Science, and ScienceDirect, using keywords such as “medicinal plants,” “liver cancer,” “hepatocellular carcinoma,” and “anticancer activity.” Findings suggest that several plant-derived compounds, including flavonoids, alkaloids, terpenoids, and polyphenols, exhibit cytotoxic effects, induce apoptosis, inhibit angiogenesis, and modulate signaling pathways in liver cancer cells. This review underscores the importance of medicinal plants as complementary or alternative strategies for HCC treatment and identifies gaps for future research to optimize their clinical applications.

Keywords

Medicinal plants, Hepatocellular carcinoma, Liver cancer, Anticancer activity, Phytochemicals.

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    © The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.