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International Journal of Zoology and Applied Biosciences Research Article

Exploring antibacterial compounds in Kalanchoe pinnata (Lam.) Pers.: GC-MS analysis and molecular docking evaluation

Parvathy Menon PR, Nirmala Devi N, Sidharth K, Reshma BP and R Ragunathan

Year : 2025 | Volume: 10 | Issue: 6 | Pages: 244-252

doi: https://doi.org/10.55126/ijzab.2025.v10.i06.027

Received on: 01/09/2025

Revised on: 12/10/2025

Accepted on: 26/10/2025

Published on: 01/11/2025

  • Parvathy Menon PR, Nirmala Devi N, Sidharth K, Reshma BP and R Ragunathan( 2025).

    Exploring antibacterial compounds in Kalanchoe pinnata (Lam.) Pers.: GC-MS analysis and molecular docking evaluation

    . International Journal of Zoology and Applied Biosciences, 10( 6), 244-252.

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Abstract

Kalanchoe pinnata (Lam.) Pers.(Miracle Leaf) in tropical and subtropical regions is widely recognized and utilized as an herbal medicine. The Role as a traditional medicine is rooted evidently in therapeutic properties for wound healing and its various bioactive compounds. This study was aimed to investigate the ethanolic extract of the Kalanchoe pinnata(Lam.) Pers leaves, Fresh Ethanolic extract of the leaves were prepared and GC-MS analysis were carried out to find the phytochemicals. The GC-MS analysis revealed 32 compounds some of them being Diethyl Phthalate, Squalene, Phytol, Dibutyl phthalate, Delta Tocopherol. The bioactive compounds revealed from the plants showed the anti-bacterial potentials that contributes to the role in wound care and its applications from pharmaceuticals. The Molecular docking was done with the bioactive compounds like squalene, Dibutyl Phthalate, Phytol, Diethyl Phthalate against the protein C-Met and GOT1 with using the drug Gemcitabine that has potential activity against the pancreatic activity. The Results suggested that Squalene and the drug shows to well interaction with protein having a binding affinity energy ranging from -7 and -7.7Kcal/mol. Based on the affinity, the C-Met and GOT1 can be used against cancer therapy using gemcitabine.

Keywords

GC-MS, Squalene, C-Met, GOT1, Gemcitabine, Kalanchoe pinnata.

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    © The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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