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International Journal of Zoology and Applied Biosciences Research Article
Detection and classification of chemokine receptor–positive immune cells
Banupriya B K, Saalini Vellivel, Kiran Kumar S, Sowmiya B and Sujitha K
Year : 2025 | Pages: 423-426
Received on: 24/09/2025
Revised on: 21/10/2025
Accepted on: 23/11/2025
Published on: 01/12/2025
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Banupriya B K, Saalini Vellivel, Kiran Kumar S, Sowmiya B and Sujitha K ( 2025).
Detection and classification of chemokine receptor–positive immune cells
. International Journal of Zoology and Applied Biosciences, 10( 6), 423-426.
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Abstract
Diabetes mellitus is strongly associated with cognitive dysfunction through complex metabolic, neuronal, and inflammatory pathways. This study investigates alterations in cognitive pathway genes using a combined in vivo diabetic model, RT-qPCR analysis, and bioinformatics validation. Streptozotocin (STZ)-induced diabetic rats were evaluated for glucose levels, behavioral impairment, and hippocampal gene expression. A panel of cognitive-related pathway genes BDNF, CREB1, SYN1, IGF-1, TNF-α, IL-6, and GLUT1 was assessed. Experimental findings demonstrated significant downregulation of neurotrophic and synaptic genes (BDNF, CREB1, SYN1) and upregulation of inflammatory mediators (TNF-α, IL-6) in diabetic hippocampal tissue. Bioinformatics analysis using diabetic cognitive datasets confirmed the expression trends and identified enriched pathways including synaptic transmission, neuroinflammation, insulin signaling, and oxidative stress. Together, the findings highlight molecular disruptions associated with diabetes-induced cognitive decline and provide validated gene markers for mechanistic and therapeutic studies.
Keywords
Diabetes, Cognitive dysfunction, BDNF, CREB1, Synaptic genes, Hippocampus.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
