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International Journal of Zoology and Applied Biosciences Research Article
Bioscientific perspectives on IVIVC: linking physicochemical properties to biological performance
Yellapu Hashika, Srinivas Rao Y and Mallikarjun P.N
Year : 2025 | Pages: 340-345
Received on: 10/09/2025
Revised on: 23/10/2025
Accepted on: 14/11/2025
Published on: 30/11/2025
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Yellapu Hashika, Srinivas Rao Y and Mallikarjun P.N ( 2025).
Bioscientific perspectives on IVIVC: linking physicochemical properties to biological performance
. International Journal of Zoology and Applied Biosciences, 10( 6), 340-345.
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Abstract
Drug development increasingly uses mathematical models linking bioavailability (BA) and bioequivalence (BE) via in vitro–in vivo correlation (IVIVC). IVIVC helps predict in vivo drug behavior from in vitro data, reduces clinical testing, and supports biowaivers, aiding tools like the Biopharmaceutical Classification System (BCS). Key factors include drug and dosage form properties, with data gathered from in vitro dissolution tests and in vivo bioavailability studies. Correlation is established using convolution and deconvolution methods connecting dissolution and pharmacokinetic data. IVIVC development involves model building, validation, and assessing internal and external predictability to ensure regulatory reliability. It mainly targets extended-release and oral forms like enteric-coated and multiple-unit systems but also apply to parenteral and nasal delivery. Computational tools such as IDEA and Gastro Plus use statistical and mechanistic models to simulate oral drug absorption, improving the efficiency and accuracy of IVIVC-driven drug development.
Keywords
Biowaivers, Convolution, Deconvolution, Validation, Novel dosage forms, In silico model Gastro plus.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
