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International Journal of Zoology and Applied Biosciences Research Article
Assessment of in vitro anti-colon cancer activity of Actinidia deliciosa methanol extract
Sibi S, Pugazh Gowrishankar, Diwakaran, Vijai Krishna V and Sujitha K
Year : 2025 | Pages: 104-107
Received on: 17/09/2025
Revised on: 19/10/2025
Accepted on: 25/10/2025
Published on: 12/11/2025
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Sibi S, Pugazh Gowrishankar, Diwakaran, Vijai Krishna V and Sujitha K ( 2025).
Assessment of in vitro anti-colon cancer activity of Actinidia deliciosa methanol extract
. International Journal of Zoology and Applied Biosciences, 10( 6), 104-107.
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Abstract
Colon cancer remains one of the most prevalent malignancies worldwide, necessitating the exploration of novel, safe, and effective therapeutic agents derived from natural sources. Actinidia deliciosa (kiwi fruit) is rich in bioactive phytochemicals, including polyphenols, flavonoids, and vitamins, which exhibit strong antioxidant and anticancer properties. The present study aimed to evaluate the in vitro anti-colon cancer activity of methanolic extract of A. deliciosa against human colon cancer cell lines. The extract was prepared through solvent extraction and subjected to preliminary phytochemical screening to identify the presence of alkaloids, flavonoids, saponins, and phenolic compounds. Cytotoxicity and antiproliferative effects were analyzed using the MTT assay, followed by assessment of apoptotic induction through morphological observation and nuclear staining. The results demonstrated a dose-dependent reduction in cell viability, indicating potent cytotoxic activity of the methanolic extract against colon cancer cells, with minimal toxicity toward normal cells. These findings suggest that A. deliciosa possesses promising anticancer potential and could serve as a source for developing plant-based therapeutics for colorectal cancer. Further purification and molecular-level studies are required to identify the active constituents responsible for the observed effects.
Keywords
Actinidia deliciosa, Methanolic extract, Colon cancer, Cytotoxicity, Apoptosis, Natural therapeutics.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
