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International Journal of Zoology and Applied Biosciences Research Article
Assessment of bioactive plant extracts for antifungal efficacy against clinical pathogens
Chandan Kumar D, Aswini L, Lavanya R, Sibi S and Jenifer E
Year : 2025 | Pages: 236-240
Received on: 15/09/2025
Revised on: 20/10/2025
Accepted on: 23/10/2025
Published on: 20/11/2025
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Chandan Kumar D, Aswini L, Lavanya R, Sibi S and Jenifer E( 2025).
Assessment of bioactive plant extracts for antifungal efficacy against clinical pathogens
. International Journal of Zoology and Applied Biosciences, 10( 6), 236-240.
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Abstract
The increasing prevalence of fungal infections and the emergence of antifungal resistance have intensified the search for safer, more effective, and sustainable therapeutic alternatives. Plant-derived bioactive compounds represent a promising reservoir of antifungal agents due to their structural diversity and multitarget mechanisms. This study investigates the antifungal efficacy of selected medicinal plant extracts against clinically significant fungal pathogens, including Candida albicans, Aspergillus niger, and Cryptococcus neoformans. Methanolic, ethanolic, and aqueous extracts of chosen plants were screened using standard in vitro assays such as well diffusion, minimum inhibitory concentration (MIC), and minimum fungicidal concentration (MFC). Phytochemical profiling was performed to identify key metabolites potentially responsible for antifungal activity. The results demonstrated substantial inhibitory and fungicidal effects, particularly in extracts rich in phenolics, flavonoids, terpenoids, and alkaloids. The study supports the therapeutic relevance of plant-based antifungal agents and highlights their potential application in developing novel antifungal formulations. Further in vivo and mechanistic studies are recommended to validate their clinical applicability.
Keywords
Airborne microplastics, Human health, Inhalation exposure, Environmental pollution, Toxicity.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
