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International Journal of Zoology and Applied Biosciences Research Article

Ameliorative effect of Vitis vinifera L. Extract against alcohol induced renal oxidative stress in male Albino rats

Thejomoorthy M, Kanchan Chatterjee, Jaya Sankar A, Dinakar Chinna T, Baskaran Maheswaran and Rajkumar N

Year : 2025 | Volume: 10 | Issue: 6 | Pages: 285-292

doi: https://doi.org/10.55126/ijzab.2025.v10.i06.033

Received on: 11/09/2025

Revised on: 20/10/2025

Accepted on: 26/10/2025

Published on: 04/11/2025

  • Thejomoorthy M, Kanchan Chatterjee, Jaya Sankar A, Dinakar Chinna T, Baskaran Maheswaran and Rajkumar N( 2025).

    Ameliorative effect of Vitis vinifera L. Extract against alcohol induced renal oxidative stress in male Albino rats

    . International Journal of Zoology and Applied Biosciences, 10( 6), 285-292.

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Abstract

This study was conducted to assess the efficacy of successive Vitis vinifera extract in mitigating nephrotoxicity induced by alcohol in rats. The assessment involved examining kidney antioxidant levels and renal damage markers. Rats were categorized into four groups (n = 6 per group): normal control (NC), Vitis vinifera treated (Vvt.t), alcohol treated (Al.t), and alcohol plus Vitis vinifera treated (Al.t + Vvt.t). The alcohol-treated group received Vitis vinifera for 30 days, and renal antioxidant enzymes were analyzed. Results showed a significant reduction (P < .001) in renal antioxidant enzymes such as Superoxide dismutase, Catalase, Glutathione peroxidase, Glutathione, in the alcohol-treated group, while malondialdehyde levels and creatinine, urea, and uric acid levels were elevated. However, supplementation of Vitis vinifera extract to the alcohol-treated rats reversed these effects, bringing the antioxidant levels and renal markers back to normal. The study suggests that Vitis vinifera extract can help alleviate alcohol-induced nephrotoxicity, making it a potential regular nutrient for protecting renal cells.

Keywords

Alcohol, Vitis vinifera, Antioxidant enzymes, MDA, Urea, Creatinine.

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    © The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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