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International Journal of Zoology and Applied Biosciences Review Article

Curcumin pharmacological property: A review on anti-inflammatory activity and human health

V. Madan Mohan Rao, Y. Shanti Prabha, Kanchan Chatterjee, Phool Gend Kumar, Sailaja C S, G. Venkata Subbaiah

Year : 2026 | Volume: 11 | Issue: 2 | Pages: 276-281

doi: https://doi.org/10.55126/ijzab.2026.v11.i02.035

Received on: 10/01/2026

Revised on: 28/01/2026

Accepted on: 21/02/2026

Published on: 01/03/2026

  • V. Madan Mohan Rao, Y. Shanti Prabha, Kanchan Chatterjee, Phool Gend Kumar, Sailaja C S, G. Venkata Subbaiah ( 2026).

    Curcumin pharmacological property: A review on anti-inflammatory activity and human health

    . International Journal of Zoology and Applied Biosciences, 11( 2), 276-281.

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Abstract

Turmeric has been documented as a spice and for its medicinal values; that attention has been made by both medicinal and culinary fanatics due to its polyphenol compound curcumin. It also worked as an antioxidant and anti-inflammatory, and other ailments include arthritis, diabetes, and cardiovascular diseases. Turmeric's major polyphenol compounds, curcuminoids, which include curcumin (diferuloyl methane), dimethoxy curcumin, and bisdemethoxycurcumin, have been evidenced as anti-inflammatory in human studies. The inflammation has shown different cascade mechanisms involving a number of molecules that are inhibited by curcumin, including cyclooxygenase-2, prostaglandin, phospholipase, lipoxygenase, thromboxane, nitric oxide, elastase, tumor necrosis factor (TNF), interleukin-12 (IL-12), monocyte chemoattractant protein-1 (MCP-1), and leukotrienes. The principal aim of this review paper is to evaluate curcumin's pharmacological anti-inflammatory properties in various diseases in humans with different mechanism of action.

Keywords

Curcumin, Anti-inflammation, phospholipase, cyclooxygenase-2, interleukin-12.

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    © The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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