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International Journal of Zoology and Applied Biosciences Research Article

Modulatory effect of Rhinacanthus nasutus on cardiac oxidative enzymes activity in STZ induced diabetic rat

N. Raj Kumar, K. Sujatha, K. Vanaja, Neha Giri, R. Chandra Mouli, R. Kamli Naik

Year : 2026 | Volume: 11 | Issue: 2 | Pages: 246-253

doi: https://doi.org/10.55126/ijzab.2026.v11.i02.031

Received on: 27/12/2025

Revised on: 08/01/2026

Accepted on: 17/12/2026

Published on: 01/03/2026

  • N. Raj Kumar, K. Sujatha, K. Vanaja, Neha Giri, R. Chandra Mouli, R. Kamli Naik ( 2026).

    Modulatory effect of Rhinacanthus nasutus on cardiac oxidative enzymes activity in STZ induced diabetic rat

    . International Journal of Zoology and Applied Biosciences, 11( 2), 246-253.

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Abstract

This study aimed to investigate the effects of Rhinacanthus nasutus administration on altered blood glucose levels, Oxidative Enzymes enzymes activity in streptozotocin-induced diabetes rats. The study divided Wistar strain rats into five groups: normal control, Rhinacanthus nasutus treated, diabetic control, diabetic plus Rhinacanthus nasutus treated, and diabetic plus glibenclamide treated groups. The diabetic group had significantly elevated blood glucose levels, which were significantly lowered by Rhinacanthus nasutus administration. The cytosolic enzyme G6PDH activity was significantly (P<0.001) decreased along with a significant increase in the LDH activity in diabetic rats heart tissue. The activities of SDH, MDH, GDH in the heart tissue of diabetic rats were significantly decreased, but the daily oral treatment of Rhinacanthus nasutus to diabetic rats for thirty days reversed the above changes in a significant (P<0.001) manner. The study demonstrated that an extract of Rhinacanthus nasutus could lower blood glucose levels, improve enzyme activities and body weight in diabetic rats. This suggests that Rhinacanthus nasutus extracts could be used as a cardio-protective supplement to reverse diabetic-induced complications.

Keywords

Diabetes, Rhinacanthus nasutus, Blood glucose, LDH, SDH, MDH, GDH.

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    © The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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