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International Journal of Zoology and Applied Biosciences Research Article
Formulation and evaluation of mucoadhesive oral sustained release tablets of etodolac to enhance bioavailability and prolong therapeutic effect
P.Ambika, B.V. Ramana, C. S. Parameswari
Year : 2026 | Volume: 11 | Issue: 2 | Pages: 155-165
Received on: 25/12/2025
Revised on: 17/01/2026
Accepted on: 14/02/2026
Published on: 01/03/2026
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P.Ambika, B.V. Ramana, C. S. Parameswari( 2026).
Formulation and evaluation of mucoadhesive oral sustained release tablets of etodolac to enhance bioavailability and prolong therapeutic effect
. International Journal of Zoology and Applied Biosciences, 11( 2), 155-165.
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Abstract
The word mucoadhesion is used when the biological substrate is a mucosal surface. With the help of mucoadhesive polymer, we target various absorptive mucosal layers of the body parts which include the ear, nose, eye, gastrointestinal tract, urogenital tract which will get attached on to the related tissue. This system of drug delivery is called as mucoadhesive drug delivery system. The mucoadhesive systems as drug a carrier has been used for maintenance of the residence time at the absorption site, performance its intensified contact with the epithelial barrier. The development of controlled drug delivery system using bioadhesive molecules includes a decrease in dose frequency and an increase in patient compliance. The present study was to formulating the mucoadhesive oral sustained release tablets containing Etodolac as an active ingredient which is used in the treatment of for the short- and long-term relief of rheumatoid arthritis and osteoarthritis. It works by relieving pain and by reducing swelling and inflammation. The present study involves Prolong release of the drug and increased bioavailability leads to significant reduction in the dose and consequently dose related side effects also reduced. In the present research work to formulate mucoadhesive oral Etodolac tablets in order to avoid extensive first pass metabolism and for prolonged effect. Mucoadhesive tablets of Etodolac were prepared by direct compression method using various bioadhesive polymers like Guar gum, gumkaraya and HPMC K15M in different concentration. The present study concludes that mucoadhesive delivery of Etodolac tablets can be a good way to presence of drug at the site of absorption and to prolong duration of action of drug by reducing the frequency of dosing of Etodolac. The optimised formulation was found to be F6 formulation and its followed peppas release kinetics.
Keywords
Mucoadhesive tablets, Etodolac, Guar gum, Gumkaraya.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
