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International Journal of Zoology and Applied Biosciences Research Article

Formulation and evaluation of mouth dissolving tablets of prochlorperazine maleate using natural superdisintegrants

C. Akshitha, B.V. Ramana, C. S. Parameswari

Year : 2026 | Volume: 11 | Issue: 2 | Pages: 143-154

doi: https://doi.org/10.55126/ijzab.2026.v11.i02.020

Received on: 28/12/2025

Revised on: 13/01/2026

Accepted on: 17/02/2026

Published on: 01/03/2026

  • C. Akshitha, B.V. Ramana, C. S. Parameswari( 2026).

    Formulation and evaluation of mouth dissolving tablets of prochlorperazine maleate using natural superdisintegrants

    . International Journal of Zoology and Applied Biosciences, 11( 2), 143-154.

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Abstract

The present study was aimed at formulation and evaluation of mouth dissolving tablets (MDTs) of Prochlorperazine maleate using natural superdisintegrants. Mouth dissolving tablets have gained significant importance due to improved patient compliance, particularly in pediatric, geriatric, and dysphagic patients. Prochlorperazine maleate, a phenothiazine antipsychotic used in the management of nausea, vomiting, and migraine, requires rapid onset of action. MDTs were prepared by direct compression method using dehydrated banana powder, karaya gum, and locust bean gum in different concentrations. A total of thirteen formulations were prepared and evaluated for precompression parameters, weight variation, hardness, thickness, friability, content uniformity, disintegration time, and in vitro drug release. Compatibility studies were performed using FTIR analysis. Dissolution studies were carried out in pH 6.8 phosphate buffer. Among all formulations, F7 was selected as the optimized formulation, showing disintegration time of 16 ± 1.42 seconds and drug release of 98.9% within 10 minutes. Stability studies conducted as per ICH guidelines showed no significant changes. The study concludes that natural superdisintegrants can effectively enhance dissolution and reduce disintegration time of Prochlorperazine maleate MDTs.

Keywords

Mouth dissolving tablets, Prochlorperazine maleate, Natural superdisintegrants, Karaya gum, FTIR.

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    © The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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