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International Journal of Zoology and Applied Biosciences Research Article
Formulation and evaluation of levofloxacin hemihydrate immediate release tablets by wet granulation technique
Ashok Kumar, C.S.Parameswari, B.V.Ramana
Year : 2026 | Volume: 11 | Issue: 2 | Pages: 125-133
Received on: 28/12/2025
Revised on: 16/01/2026
Accepted on: 19/02/2026
Published on: 01/03/2026
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Ashok Kumar, C.S.Parameswari, B.V.Ramana( 2026).
Formulation and evaluation of levofloxacin hemihydrate immediate release tablets by wet granulation technique
. International Journal of Zoology and Applied Biosciences, 11( 2), 125-133.
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Abstract
The present study was undertaken to formulate and evaluate immediate release tablets of Levofloxacin hemihydrate using the wet granulation method. The objective was to develop a formulation comparable to the innovator product (Levaquin®) with improved disintegration and dissolution characteristics. Pre-formulation studies including description, solubility, loss on drying, melting point, flow properties, sieve analysis, and compatibility studies were performed. Levofloxacin hemihydrate exhibited good physicochemical properties suitable for formulation development. Tablets were prepared using microcrystalline cellulose as diluent, croscarmellose sodium as superdisintegrant, crospovidone as binder, and magnesium stearate as lubricant. The prepared tablets were evaluated for hardness, thickness, friability, weight variation, disintegration time, and in vitro dissolution. Among eight formulations (F1–F8), formulation F8 showed optimized performance with acceptable mechanical strength, rapid disintegration, and dissolution profile comparable to the innovator product (f2 similarity factor ? 66.64). Stability and processing feasibility confirmed its suitability for large-s cale production. The study concludes that wet granulation is an effective and reproducible method for developing Levofloxacin immediate release tablets with equivalent performance to marketed products.
Keywords
Levofloxacin hemihydrate, Immediate release tablets, Wet granulation, Superdisintegrant.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
