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International Journal of Zoology and Applied Biosciences Research Article
Formulation and evaluation of immediate release acyclovir tablets by wet granulation method
S.P. Navya Sruthi, C.S.Parameswari, B.V.Ramana
Year : 2026 | Volume: 11 | Issue: 2 | Pages: 118-124
Received on: 27/12/2025
Revised on: 14/01/2026
Accepted on: 18/02/2026
Published on: 01/03/2026
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S.P. Navya Sruthi, C.S.Parameswari, B.V.Ramana( 2026).
Formulation and evaluation of immediate release acyclovir tablets by wet granulation method
. International Journal of Zoology and Applied Biosciences, 11( 2), 118-124.
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Abstract
The present study aimed to formulate and evaluate pharmaceutically equivalent immediate release Acyclovir tablets using different superdisintegrants by wet granulation technique. Acyclovir, a nucleotide reverse transcriptase inhibitor with antiviral activity against HSV and VZV, exhibits poor oral bioavailability, necessitating optimized formulation strategies. Tablets were prepared using varying concentrations of crospovidone and croscarmellose sodium as super disintegrants along with microcrystalline cellulose, lactose, pregelatinized starch, and magnesium stearate. Preformulation studies including angle of repose, bulk density, tapped density, compressibility index, Hausner’s ratio, solubility, loss on drying, melting point, and hygroscopicity were performed. Post-compression evaluation included weight variation, hardness, thickness, friability, water content, drug content, and in vitro disintegration and dissolution studies. Drug release studies were carried out in 0.1N HCl using USP dissolution apparatus. The optimized formulation showed acceptable physicochemical parameters, satisfactory hardness, low friability, uniform drug content, rapid disintegration, and enhanced drug release comparable to marketed formulation. The developed formulation was found to be stable and pharmaceutically equivalent. The study concludes that optimized immediate release Acyclovir tablets can provide improved therapeutic performance and patient compliance.
Keywords
Acyclovir, Immediate Release Tablets, Wet Granulation, Super disintegrants, Crospovidone.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
