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International Journal of Zoology and Applied Biosciences Research Article
Formulation optimization and quality assessment of Orodispersible chewable tablets of loratadine
B Gayathri, B.V. Ramana, C. S. Parameswari
Year : 2026 | Volume: 11 | Issue: 2 | Pages: 94-99
Received on: 26/12/2025
Revised on: 19/01/2026
Accepted on: 17/02/2026
Published on: 01/03/2026
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B Gayathri, B.V. Ramana, C. S. Parameswari( 2026).
Formulation optimization and quality assessment of Orodispersible chewable tablets of loratadine
. International Journal of Zoology and Applied Biosciences, 11( 2), 94-99.
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Abstract
The present study was undertaken to formulate and optimize orodispersible chewable tablets of Loratadine with the objective of improving its solubility, dissolution rate, and oral bioavailability. Loratadine, a poorly water-soluble antihistaminic drug, exhibits limited dissolution characteristics, which may reduce its therapeutic effectiveness. To enhance drug release, super disintegrating agents such as maize starch, mannitol, and croscarmellose sodium were incorporated in varying concentrations to promote rapid disintegration by increasing tablet porosity and facilitating faster penetration of dissolution medium. All formulations were prepared by the direct compression method using an 8 mm punch on an 8-station rotary tablet compression machine. The pre-compression parameters of the powder blends, including angle of repose, bulk density, and tapped density, demonstrated good flow properties, indicating suitability for direct compression. The compressed tablets were evaluated for post-compression parameters such as hardness, thickness, friability, weight variation, drug content uniformity, disintegration time, and in-vitro dissolution studies. All formulations complied with the official limits specified in the Indian Pharmacopoeia. Among the prepared formulations, F6 showed the highest percentage drug release of 94.6% within 45 minutes and was identified as the optimized formulation. The enhanced performance of F6 was attributed to the presence of croscarmellose sodium at a concentration of 60 mg, which significantly improved tablet disintegration and dissolution. The results suggest that optimized orodispersible chewable tablets of Loratadine can be successfully developed to achieve improved drug release characteristics.
Keywords
Loratadine, Orodispersible chewable tablets, Superdisintegrants, Croscarmellose sodium.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
