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International Journal of Zoology and Applied Biosciences Research Article
2-Carbamyl-9-[Beta-D-Ribofuranosyl] hypoxanthine from Rambutan fruit as potential inhibitor of apoptotic proteins: In silico molecular docking approach
Angalammal P, Sivakumari K, Rajesh S and Shyamala Devi K
Year : 2022 | Pages: 1-6
Received on: 2022-10-14
Revised on: 2022-10-27
Accepted on: 2022-11-01
Published on: 11/07/2022
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Angalammal P, Sivakumari K, Rajesh S and Shyamala Devi K( 2022).
2-Carbamyl-9-[Beta-D-Ribofuranosyl] hypoxanthine from Rambutan fruit as potential inhibitor of apoptotic proteins: In silico molecular docking approach
. International Journal of Zoology and Applied Biosciences, ( ), 1-6.
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Abstract
The fruit of the rambutan tree, Nepheliumlappaceum, is an important source of physiologically active substances that have the ability to induce apoptosis. Because of this, the goal of the current work was to anticipate how the GC-MS spectrum compound from Nepheliumlappaceum (2-Carbamyl-9-[Beta-D-Ribofuranosyl] Hypoxanthine]) would interact with apoptotic proteins (Caspase-3, Caspase-9, -Actin, p53, and Bcl-2) using the PatchDock docking program. As a result of the Lipinski rule, 2-Carbamyl-9-[Beta-D-Ribofuranosyl] Hypoxanthine is recommended as the best cancer treatment. The use of a molecule as a potential natural medicinal agent to treat disease is demonstrated through docking studies.
Keywords
Rambutan, GC-MS, Molecular Docking, PatchDock, Apoptotic Proteins.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
