International Journal of Zoology and Applied Biosciences
Volume (1) - Issue (3), 2016 pp 173-180
Title
Comparative modelling of tertiary structures of two viral proteins from Bombyx mori
Author
Chittaranjan Baruah, Papari Devi, Jayanta Deka, D.K. Sharma
Abstract
The non-diapausing silkworm Bombyx mori is exploited both as a powerful biological model system and also as a tool to convert leaf protein into silk. Silkworm often suffers from viral infections causing heavy losses to the economy of the silk industry. One of the main virus pathogens is a nucleopolyhedrovirus, B. mori NPV (BmNPV). The present study is extended to Homology modelling of two important proteins- DNA-binding protein (DBP) and Late expression factor II (LEF-II) extracted from the UNIPROKB/SWISSPROT database. Further, the verified 3D structures were deposited to PMDB (PMDB Ids: PM0074795 and PM0074790) and concerned for characterization using structure and sequence based function prediction tools. The investigation will be helpful in understanding the molecular aspects of antiviral immunity in silkworm.
Keywords
Antiviral activity, Baculoviridae, BmNPV, Homology modeling.
Article History
Received on 03/06/2016, Accepted on 14/06/2016, Published on 30/06/2016
