International Journal of Zoology and Applied Biosciences
Volume (1) - Issue (2), 2016 pp 94-99
Title
An insilico study: characterization of wd repeat protein family in different species of mosquitos
Author
Sivakolundu Mahesh Babu, Mathalaimuthu Baranitharan, Shanmugam Dhanasekaran and Subbaiyan Thushimenan
Abstract
In the present investigation, the WD-repeat (WDR) proteins comprise an astonishingly diverse superfamily of regulatory proteins. To date, genome-wide characterization of this family has only been conducted in mosquito and little is known about WDR genes in mosquito (Aedes, Anopheles and Culex). This study identified 15 mosquito WDR genes in the latest genome and the WDR family contained a smaller number of identified genes compared to different species of mosquitoes. The WDR proteins were identified and classified in to different subfamilies based on their distinct domain organizations. Although many characteristics of the protein family are similar to those species, several features are quite distinct. Our result of Insilco analysis indicated the existence of well-conserved subfamilies. Moreover, comparative genomic analysis showed that the gene structures of the WDR protein were highly conserved across some different lineage species. Through functional divergence analysis, a substantial divergence was found between WDR protein subfamilies.
Keywords
WD-repeat, Aedes aegypti, Physiochemical Properties, Sequence alignment, Phylogenetic tree.
Article History
Received on 03/03/2016, Accepted on 23/04/2016, Published on 24/04/2016
