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International Journal of Zoology and Applied Biosciences Research Article

Toxicological studies of Ageratum conyzoides in rats

Harisha. C. B, Shridhar, N.B., Sunilchandra, U., Prashant Kumar Waghe, Kavitha Rani, B., Patel Suresh Revanna, Vinuta M.H., Niranjan.D

Year : 2023 | Volume: 8 | Issue: 3 | Pages: 32-52

doi: https://doi.org/10.55126/ijzab.2023.v08.i03.006

Received on: 2023-04-19

Revised on: 2023-04-26

Accepted on: 2023-05-12

Published on: 05/26/2023

  • Harisha. C. B, Shridhar, N.B., Sunilchandra, U., Prashant Kumar Waghe, Kavitha Rani, B., Patel Suresh Revanna, Vinuta M.H., Niranjan.D( 2023).

    Toxicological studies of Ageratum conyzoides in rats

    . International Journal of Zoology and Applied Biosciences, 8( 3), 32-52.

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Abstract

The study was taken up to evaluate the pharmacological and toxicological property of A. conyzoides plant. The yield of methanolic extract was found to be 6.8 %. The pH of methanolic extract of A. conyzoides (MEAC) was 5.86. It was dark green in colour and the was dry and powdery in consistency with aromatic odour. Acute oral and repeated dose 28-day oral toxicity studies of methanolic extract was carried out in Wistar albino rats as per the OECD guidelines 423 and 407 respectively. In sub-acute oral toxicity dose levels of 500, 1000 and 1500 mg/kg were administered daily for 28 days and compared with the control rats. In toxicity studies, no mortality and toxicity signs were observed. The MTD value was found to be more than 5000 mg/kg. The general condition of the animals did not change and all the animals remained in normal health condition throughout the experiment. The histopathological changes were dose dependent and the changes were very mild to moderate and are not the major signs to conclude the extract are toxic in acute stage, in repeated dose toxicity study showed the alarming signs of toxicity. Haematological and biochemical parameters showed significant effect of the extract on different organs which are evident by histopathological changes observed in extract treated groups.

Keywords

A. conyzoides, phytochemical analysis, Anti-inflammatory activity, Toxicity study and Wistar albino rats.