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International Journal of Zoology and Applied Biosciences Research Article
Antioxidant status anticancer and hepato protective efficacy of Macrotyloma uniflorum seeds an In-vitro approach
Manikandan Mathaiyan, Suriyavathana Muthukrishnan, Sobiya pradeep and Thamaraiselvi Ganesan
Year : 2023 | Volume: 8 | Issue: 1 | Pages: 8-19
Received on: 11/19/2022
Revised on: 11/30/2022
Accepted on: 12/26/2022
Published on: 01/08/2023
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Manikandan Mathaiyan, Suriyavathana Muthukrishnan, Sobiya pradeep and Thamaraiselvi Ganesan( 2023).
Antioxidant status anticancer and hepato protective efficacy of Macrotyloma uniflorum seeds an In-vitro approach
. International Journal of Zoology and Applied Biosciences, 8( 1), 8-19.
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Abstract
The Macrotyloma uniflorum seeds (Horse gram) has been underutilized pulse around the world. Nevertheless, it contains most valuable nutritional and pharmacological phytochemicals. Thus, this research was performed to evaluate the antioxidant, anticancer, and hepatoprotective potential of horse gram methanol extract. Interestingly, methanol extract of horse gram demonstrated dose dependent antioxidant, anticancer, and hepatoprotective activities. Since, at increased (100 mg mL-1) concentration the methanolic extract scavenged the DPPH radical up to 93.5% and reduced the ferric (Fe3+) into ferrous (Fe2+) up to 95%. Similarly, the methanol extract also possess considerable anticancer activities up to 75.64% at 300 mg mL-1 concentration. Furthermore, at increased concentration (300 mg mL-1), the methanol extract effectively protect (hepatoprotective) the HEK293 cells (95.71%), which exposed to 100 mM glucose (hepatotoxicity). The obtained results conclude that the horse gram methanol extract contains pharmacologically valuable phytochemicals and that regular intake of horse gram can be recommended to improve human health.
Keywords
Macrotyloma uniflorum, Antioxidant, Anticancer, Cytotoxicity, Nephroprotectivity.
