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International Journal of Zoology and Applied Biosciences Research Article

Pharmacological evaluation and antifertility activity of Aristolochia indica in rats

Nasir Aahmad Dar, Abha Upadhyay and Deepak Kumar Mittal

Year : 2021 | Volume: 6 | Issue: 3 | Pages: 114-106

doi: https://doi.org/10.5281/zenodo.4959023

Received on: 03/10/2021

Revised on: 04/20/2021

Accepted on: 04/22/2021

Published on: 06/15/2021

  • Nasir Aahmad Dar, Abha Upadhyay and Deepak Kumar Mittal( 2021).

    Pharmacological evaluation and antifertility activity of Aristolochia indica in rats

    . International Journal of Zoology and Applied Biosciences, 6( 3), 114-106.

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Abstract

Pharmacological and antifertility activity evaluation of Aristolochia indica in rats. The antifertility activity of the extracts of A. indica in rats was evaluated using two experimental animal models. Anti-implantation and early abortifacient activity was performed in female Wistar rats by determining the number of implantations and implantation resorptions. In estrogenic activity evaluations, the ethanolic and aqueous extracts offered significant estrogen-like activity at 200 mg kg−1 p.o. by increasing the uterine weight compared to vehicle control group. Ethanolic extract (200 mg kg−1, p.o.) treatment significantly decreased the number of implants and increased the number of resorptions compared to vehicle control group. The results of the present study provide the evidence of the anti-fertility activity of A. indica as claimed in the traditional use. The results are consistent with the literature reports related to the antifertility effect of flower extracts of A. indica.

Keywords

Antifertility, Aristolochia indica, Anti implantation, Rats.

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