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International Journal of Zoology and Applied Biosciences Research Article
Hypolipidemic activity of flavonoids from banana (Musa paradisiaca) in rat fed high fat diet
S. Vijayakumar* and Vijayalakshmi, N.R.
Year : 2020 | Volume: 5 | Issue: 1 | Pages: 27-31
Received on: 02/16/2020
Revised on: 02/23/2020
Accepted on: 02/25/2020
Published on: 02/29/2020
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S. Vijayakumar* and Vijayalakshmi, N.R.( 2020).
Hypolipidemic activity of flavonoids from banana (Musa paradisiaca) in rat fed high fat diet
. International Journal of Zoology and Applied Biosciences, 5( 1), 27-31.
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Abstract
Oral administration of banana (Musa paradisiaca) flavonoids have health benefit ie., hypolipidemic effect even in rats fed high fat diet. Banana is the richest source of polyphenolic compounds. Banana is one of the oldest fruits of the world. It is found that the effective dosage of banana flvonoid is 1 mg/ 100 g BW. Concentration of cholesterol, phospholipid, triglycerides,etc. decreased in experimental animals. The activity of enzymes such as HMG CoA reductase, glucose-6 phosphate dehydrogenase etc. were significantly reduced. Significant enhancement was noticed in the activities of LCAT and lipoprotein lipase. The concentration of hepatic and faecal bile acids and faecal neutral sterols were also noticed in the experimental animals, indicating a higher rate of cholesterol degradation. The hypolipidemic activity of flavonoids showed that process of cholesterol degradation exceeds the rate of its synthesis.
Keywords
Flavonoids, high fat diet, hypolipidemia, Musa paradisiaca.
