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International Journal of Zoology and Applied Biosciences Research Article
An insilico study: characterization of wd repeat protein family in different species of mosquitos
Sivakolundu Mahesh Babu, Mathalaimuthu Baranitharan, Shanmugam Dhanasekaran and Subbaiyan Thushimenan
Year : 2016 | Volume: 1 | Issue: 2 | Pages: 94-99
Received on: 03/03/2016
Revised on: 04/22/2016
Accepted on: 04/23/2016
Published on: 04/24/2016
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Sivakolundu Mahesh Babu, Mathalaimuthu Baranitharan, Shanmugam Dhanasekaran and Subbaiyan Thushimenan( 2016).
An insilico study: characterization of wd repeat protein family in different species of mosquitos
. International Journal of Zoology and Applied Biosciences, 1( 2), 94-99.
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Abstract
In the present investigation, the WD-repeat (WDR) proteins comprise an astonishingly diverse superfamily of regulatory proteins. To date, genome-wide characterization of this family has only been conducted in mosquito and little is known about WDR genes in mosquito (Aedes, Anopheles and Culex). This study identified 15 mosquito WDR genes in the latest genome and the WDR family contained a smaller number of identified genes compared to different species of mosquitoes. The WDR proteins were identified and classified in to different subfamilies based on their distinct domain organizations. Although many characteristics of the protein family are similar to those species, several features are quite distinct. Our result of Insilco analysis indicated the existence of well-conserved subfamilies. Moreover, comparative genomic analysis showed that the gene structures of the WDR protein were highly conserved across some different lineage species. Through functional divergence analysis, a substantial divergence was found between WDR protein subfamilies.
Keywords
WD-repeat, Aedes aegypti, Physiochemical Properties, Sequence alignment, Phylogenetic tree.
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© The Author(s) 2025. This article is published by International Journal of Zoology and Applied Biosciences under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
